Study Reveals TREM1’s Role in Disrupting Myeloid Bioenergetics and Cognitive Function in Aging and Alzheimer’s Disease Mouse Models

Groundbreaking findings on the role of TREM1 in disrupting myeloid bioenergetics and cognitive function in aging and Alzheimer’s disease mouse models. Trem1 deficiency prevents age-dependent changes in myeloid metabolism, inflammation, and hippocampal memory function in mice. The study provides insights from postmortem Alzheimer’s disease brain samples, revealing the potential role of TREM1 in promoting cognitive decline in aging and in the context of amyloid pathology.