Enzyme Checkpoint Identified in Tumor-Associated Macrophages

A recent study has identified an enzyme, phosphoglycerate dehydrogenase (PHGDH), as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs), affecting tumor growth. Targeting PHGDH could be a new approach in cancer treatment, potentially improving the effectiveness of clinical immunotherapies. The study utilized innovative methods, including AI and machine learning, to diagnose metabolic markers and identify checkpoints, leading to the discovery of the metabolic checkpoint in macrophage polarization.