JAX Researchers Develop Platform to Study Genetic Diversity in Mutation Outcomes

JAX researchers at The Jackson Laboratory have developed a powerful platform using stem cells from eight different mouse strains to mimic genetic diversity, providing new opportunities for uncovering targets for therapeutic interventions. The platform allows for investigating the effects of background genetics on the DYRK1A gene, associated with autism, microcephaly, and intellectual disability in humans. This work has significant implications for understanding the role of genetic diversity in human health conditions and for identifying potential targets for therapeutic intervention.