Researchers Make Strides in Understanding LAG-3 Protein
Researchers at Stanford University and New York University have made significant strides in understanding the properties of the LAG-3 protein, shedding light on its structure and function. This breakthrough could have far-reaching implications for the development of immune checkpoint inhibitor drug candidates targeting LAG-3. The study, published in Proceedings of the National Academy of Sciences, provides crucial insights into the molecular structure of LAG-3 and how it operates. LAG-3, like other checkpoint proteins, serves to prevent the immune system from attacking non-threatening entities. In the context of cancer, these proteins can shield tumor cells from immune recognition, hindering the body’s natural defense mechanisms. While existing antibody treatments focus on checkpoint proteins CTLA-4 and PD-1, the unique mode of action of LAG-3 presents an opportunity for novel approaches in cancer therapy. Scientists are optimistic about the potential of targeting LAG-3, driven by its distinct mechanisms compared to CTLA-4 and PD-1.
Enzyme Checkpoint Identified in Tumor-Associated Macrophages
A recent study has identified an enzyme, phosphoglycerate dehydrogenase (PHGDH), as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs), affecting tumor growth. Targeting PHGDH could be a new approach in cancer treatment, potentially improving the effectiveness of clinical immunotherapies. The study utilized innovative methods, including AI and machine learning, to diagnose metabolic markers and identify checkpoints, leading to the discovery of the metabolic checkpoint in macrophage polarization.
The Interconnected Nature of Spring Allergies
Learn how spring allergies can affect multiple systems within the body, from nasal allergies and asthma to eczema and eye allergies. Understanding the interconnected nature of allergic responses is crucial for effectively managing and improving quality of life for those affected.
Study Finds Long-Lasting Effects of Smoking on Immune System
A recent study published in Nature found that cigarette smoking can have long-lasting effects on the immune system, persisting even after quitting. The study analyzed the immune responses of 1,000 individuals and also identified a higher body mass index and previous cytomegalovirus infection as influential factors. These findings emphasize the enduring consequences of lifestyle choices on immune function and shed light on the long-term impact of smoking on overall health.
MIT and Ragon Institute researchers make breakthrough in DNA-based vaccine development
Researchers from MIT and the Ragon Institute of MGH, MIT, and Harvard have made a significant breakthrough in vaccine development. They have created a vaccine using a virus-like delivery particle made from DNA, which has shown promise in inducing a…
Israeli Institute Discovers New Cancer Treatment Using Immune Cells
Israeli Institute Finds New Effective Cancer Treatment Using Immune Cells Researchers at the Weizmann Institute of Science in Rehovot have made a groundbreaking discovery in the battle against cancer. They have developed a new kind of immunotherapy based on intercommunication…
New Nanotherapy Offers Breakthrough in Allergy Treatment
Northwestern University researchers have made a groundbreaking discovery in the field of allergy treatment. They have developed a new therapy that can selectively prevent allergic reactions without suppressing the entire immune system. The therapy involves decorating nanoparticles with antibodies capable…
Investigating Why Vaccines Don’t Work as Well in Older Adults
An important aspect of aging is how the immune system changes over time, which has consequences and contributes to the greater risk for severe infections and other diseases such as cancer in the aging population. Researchers at The Jackson Laboratory…