Mitonuclear incompatibility in swordtail fish sheds light on speciation mechanisms
The evolution of reproductive barriers is the first step in the formation of new species and can help us understand the diversification of life on Earth. These reproductive barriers often take the form of hybrid incompatibilities, in which alleles derived…
Naturally Occurring Variant of SHLP2 May Offer Protection Against Parkinson’s Disease, Study Finds
Researchers have identified a naturally occurring variant of SHLP2 that may offer protection against Parkinson’s disease (PD). The study, published in Molecular Psychiatry, delves into the functional role of a mitochondrial DNA single nucleotide polymorphism (mtSNP) associated with reduced PD…
New Study Reveals 11,000 Vital Genetic Switches in Every Cell Type
Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code. New evidence challenges the simplistic view that cis-regulatory elements (CREs) are mere on/off switches for genes, emphasizing their…
RNA-Based Switch for Gene Therapy
An RNA-Based Switch for Dialing Gene Therapy Up or Down January 2, 2024 The ability to control the expression of therapeutic genes within a “therapeutic window” is crucial to ensure the development of safe and effective gene therapies, but to…