Breakthrough in Understanding Cancer Cell Adaptation to Low Oxygen Environments

Researchers at the Francis Crick Institute have discovered how cancer cells adapt to low oxygen environments, offering potential insights into preventing therapy resistance. The study revealed that cancer cells increase glycolysis within three hours of oxygen deprivation, independent of HIF1α, with the crucial role of enzymes LDHA and GOT1 in regulating the process. This breakthrough could have implications for targeting treatment-resistant cancer cells within tumors with limited oxygen access.