Researchers Make Strides in Understanding LAG-3 Protein
Researchers at Stanford University and New York University have made significant strides in understanding the properties of the LAG-3 protein, shedding light on its structure and function. This breakthrough could have far-reaching implications for the development of immune checkpoint inhibitor drug candidates targeting LAG-3. The study, published in Proceedings of the National Academy of Sciences, provides crucial insights into the molecular structure of LAG-3 and how it operates. LAG-3, like other checkpoint proteins, serves to prevent the immune system from attacking non-threatening entities. In the context of cancer, these proteins can shield tumor cells from immune recognition, hindering the body’s natural defense mechanisms. While existing antibody treatments focus on checkpoint proteins CTLA-4 and PD-1, the unique mode of action of LAG-3 presents an opportunity for novel approaches in cancer therapy. Scientists are optimistic about the potential of targeting LAG-3, driven by its distinct mechanisms compared to CTLA-4 and PD-1.
Analysis of Plasma Antibody Levels in Severe COVID-19 Patients
Analysis of related factors of plasma antibody levels in patients with severe and critical COVID-19 By Yudi Xie, Yang Xia, Haixia Xu, Jue Wang, Wei Zhang, Ling Li & Zhong Liu Coronavirus disease 2019 (COVID-19) continues to impact global public…
MIT and Ragon Institute researchers make breakthrough in DNA-based vaccine development
Researchers from MIT and the Ragon Institute of MGH, MIT, and Harvard have made a significant breakthrough in vaccine development. They have created a vaccine using a virus-like delivery particle made from DNA, which has shown promise in inducing a…
New Nanotherapy Offers Breakthrough in Allergy Treatment
Northwestern University researchers have made a groundbreaking discovery in the field of allergy treatment. They have developed a new therapy that can selectively prevent allergic reactions without suppressing the entire immune system. The therapy involves decorating nanoparticles with antibodies capable…