Expecting mothers with epilepsy face numerous considerations when it comes to managing their condition while pregnant. A recent study published in the journal Neurology sheds light on the impact of newer epilepsy medications on children’s creativity when taken during pregnancy.

The study, conducted by researchers, revealed that newer epilepsy drugs administered during pregnancy do not appear to affect the creative thinking abilities of children. This finding contrasts with previous observations related to older medications, indicating a potential shift in outcomes for children of epileptic mothers.

Researchers assessed creativity scores in children at the age of 4, comparing offspring of mothers with epilepsy to those of healthy mothers. Surprisingly, no significant differences in creativity were noted between the two groups. Additionally, variations in creativity were not observed across different levels of anti-seizure medications present in the mothers’ blood samples during the third trimester.

However, the study did identify a correlation between higher concentrations of epilepsy drugs in the mother’s bloodstream during the third trimester and compromised performance in tests measuring executive function in children. Executive function encompasses crucial cognitive skills such as working memory, flexibility, and inhibition control.

The research emphasized that while newer epilepsy medications are generally considered safe for use during pregnancy, careful dosage adjustments are essential to strike a balance between seizure control and minimizing potential adverse effects on the developing child. Dr. Kimford Meador, a neurology professor at Stanford University and one of the study’s researchers, highlighted the importance of optimizing medication dosages to safeguard both maternal health and child development.

The study involved 251 children of mothers with epilepsy and 73 children of mothers without the disorder. Most epileptic mothers were prescribed a single medication to manage their seizures. At the age of 4, the children underwent testing involving creative tasks, such as completing drawings or adding personal illustrations.

Despite the study’s insights, researchers underscored the need for further investigation into the comprehensive impact of anti-seizure medications on fetal development. Dr. Meador emphasized the necessity of additional studies, particularly focusing on older children, to fully comprehend the implications of these medications on childhood cognitive development.

Expectant mothers grappling with epilepsy are advised to engage in thorough discussions with their healthcare providers to determine the most suitable medication regimen that minimizes risks to both maternal and fetal well-being.

For more information on epilepsy, interested individuals can refer to resources provided by Harvard Medical School.

SOURCE: American Academy of Neurology, news release, May 29, 2024